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KMID : 1004820080090020029
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Journal of Biomedical Research
2008 Volume.9 No. 2 p.29 ~ p.36
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Anti-inflammatory Effects of an Ethanolic Extract of Angelica gigas in a Thermal Burn Model
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Shin Sun-Hee
Park Dong-Sun
Jeon Jeong-Hee
Kim Jeong-Seon
Park Sung-Kyeong
Kim Yun-Bae
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Abstract
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Anti-inflammatory effects of ethanolic extract of Angelica gigas (EAG 50, 150, and 500 mg/kg) were investigated in thermal burn-paw edema model. Immersion of rat hind legs into 48.5℃ water for 50 secincreased the leg volume by 0.46 - 0.55 ml. EAG attenuated not only the paw volume in a dosedependent manner, but also blood lymphocyte counts and interleukin-6 level increased by burns, without influence on the level of tumor-necrosis factor-α. Moreover, EAG reduced alkaline phosphatase level, a parameter of hepatic injury, which was increased by thermal burns. The results indicate that EAG
attenuates inflammatory symptoms induced by thermal burn and EAG or its coumarin derivatives could be a promising anti-inflammatory drug candidate in inflammation diseases.
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KEYWORD
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inflammation, Angelica gigas, thermal burn
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